Design and tactics towards synthesis of 10 & 14-membered macrocyclic lactones and lewis acid mediated regioselective C-C bond formation

Abstract

The thesis hereby presents a unique perspective for retrosynthetic design and state-of-the-art strategies towards enantioselective synthesis of 10 and 14-membered macrolactones, along with the development of Lewis acid mediated scalable methods for C−C bond formation.