Abstract:
The thesis titled “Catalytic synthesis of P-chiral supramolecular phosphines, their self-assembled metal
complexes and implication in asymmetric catalysis” is divided into six different chapters. Chapter-1
deals with the detailed literature survey on the chiral supramolecular phosphine ligands and their
self-assembled metal complexes. Various chiral supramolecular phosphine ligand and their selfassembled
metal complexes used in asymmetric catalysis such as hydrogenation and
hydroformylation will be discussed.1 Synthetic aspects of all these chiral supramolecular
phosphine ligands will be highlighted.
2
In addition to this, on the basis of backbone chirality, the
chiral supramolecular phosphine ligands have been subdivided into two parts, 1) C-chiral
backbone supramolecular phosphines, and 2) Axially chiral supramolecular phosphines. Chapter2
deals with the synthesis and characterization of (Me-Duphos)-Pd complexes and their application
towards the enantioselective synthesis of P-chiral supramolecular phosphine. Chapter-3 describes
the Pd-catalyzed synthesis of a library of P-chiral supramolecular phosphine ligands under mild
conditions via enhancing the rate of P-C coupling reaction through rational catalyst selection. The
nickel catalyzed synthesis of P-chiral supramolecular phosphine ligands is illustrated in Chapter4.
Chapter-5 deals with the implication of P-chiral supramolecular phosphine ligands and their
self-assembled metal complexes in asymmetric hydrogenation. Chapter-6 concludes the work and
provides future direction.
