Abstract:
The present thesis demonstrates the importance of aryne in the construction of C–C, C–S, and C–N bonds,
which result in the synthesis of the biologically important scaffolds. Chapter 1 presents the introduction
of aryne and its mode of reactivity especially leading to the difunctionalization of arenes. It comprises
insertion, pericyclic, annulation and multicomponent reactions of aryne and their representative examples.
Chapter 2 deals with difunctionalization of aryne to form sulfones and xanthones, which is further divided
into two sections. Section 1 presents the transition-metal-free synthesis of sulfones using aryne chemistry.
We were able to synthesize diaryl as well as alkyl aryl sulfones in excellent yields. Section 2 reveals the
effort towards the total synthesis of diversonol natural product. Chapter 3 demonstrates the novel process
for the synthesis of varyingly substituted oxindolylidene acetates in good yields. This method has been
further extended to the one-pot synthesis of spiroxindolopyrrolidones. Chapter 4 describes the utilization
of aryne in the general synthesis of octahydroquinoline scaffold in a stereoselective manner.
