Abstract:
The aim of this thesis was to design and develop non-woven nanofibers by
electrospinning method for drug delivery application. Accordingly, new
underutilized polymers were studied for drug delivery applications by
blending with biopolymers, which are safe for the environment. All the
nanofibers developed in this research work were subjected to characterization
by various physicochemical method and their efficacy were studied by in vitro
and in vivo analysis. In Chapter 1, we reviewed the literature on the
nanofibers developed by electrospinning method and application in various
field was explained. And the effect of parameters on nanofibers were
explained briefly. Chapter 2 investigates the objectives and scope of the work
carried out in this thesis. In Chapter 3, we prepared a non-woven nanofibers
using the combination of hydrophobic polymers (PLA and PCL) and
hydrophilic protein (EA) to understand its applicability in tissue engineering.
Chapter 4 deals with the fabrication of hyaluronic acid nanofibers by blending
with PHBV, HA and PEO and immobilized Curcumin and CDF to evaluate its
anti-bacterial property. In the chapter 5, we developed a dual drug loaded
nanofibers system using blends of neem oil based polyesteramide for wound
healing application and to overcome bacterial resistance. Chapter 6 developed
nanofibers by NPEA, PCL, and PLA embedded with SMN by electrospinning
method for targeted drug delivery application. Chapter 7 summarises the
overall work done in this thesis and proposes the area of research
consideration for drug delivery applications. It also illustrates how
nanofibers might be used to treat wound healing, tissue engineering, and drug
delivery while overcoming the limitations of conventional treatments.
